Ok, so I see that your second column, the Brian folder is basically the exact same as the Brian folder in third column under Users folder. This is not duplicate folders, but just duplicate presentation, which can be turned off by going to File Explorer > Three dots > Options > View tab. Turn off the option "Show all folders".

Your OneDrive looks fine, there's no issue there. The yellow folder Documents is a standard OneDrive folder, it comes with every OneDrive account, just like the Attachment folder, they cannot be deleted. The gray-ish Documents folder is the Windows user shell folder, meaning your OneDrive is backing it up at the moment, or it was backed up at one point.
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now let's talk about your other goals:
Backup your E drive Data folder .
My original suggestion still applies. create a folder called EDriveData in E:, then put files and folders you want to back up to OneDrive into E:\EDriveData.
Then in C:\users\YourName\OneDrive folder, create a folder also called EDriveData.
Then, Please type cmd in the search on the taskbar. Don't press enter key yet. Instead, choose "run as administrator" to launch Command Prompt.
Run this command:
mklink /d "C:\Users\Brian\OneDrive\EDriveData" "E:\EDriveData"
This will allow OneDrive to backup everything that lives in E:\EDriveData.
**Backing up ****C:\Users\Brian\Documents\Outlook Files.
**You cannot just backup one folder, or selective files in C:\Users\Brian\Documents\ to OneDrive. It is either the entire folder, or none. You can instead, move the OUtlook Files to C:\Users\Brian\OneDrive\Documents instead, but by doing so, you need to make sure you update your Outlook's user profile file. Are you using Outlook Classic?